Metabolic Imaging & Tissue engineering Group News

Prof. D. Papkovsky and Dr. A. Zhdanov have participated in recent study published in Cell Host & Microbe journal. In collaboration with Prof. U. Knaus and Dr. G. Aviello (University College Dublin) they studied the production of reactive oxygen species in NOX-dimerization partner knock-out mice during the infection of colon by various bacteria strains. The full text can be found here .

Dr. R. Dmitriev, PhD candidate J. Jenkins and Prof. D. Papkovsky, in collaboration with Regensburg Institute of Organic Chemsitry and Roche Diagnostics (Germany), have developed a new fluorescent "turn-on" probe for NAD(P)H detection in cancer cells. Such red fluorescent probe works in "end-point" assay formats, however it is highly compatible with both 2D (adherent cell cultures) and 3D (tumour spheroid) cell models. The probe can be used for multi-parametric imaging of cell metabolism in advanced in vitro and  ex vivo models of cancer. The manuscript published in ACS Sensors journal can be found here .