Metabolic Imaging & Tissue engineering Group News

Dr. R. Dmitriev  performed and co-authored a collaborative study together with groups from Russia (Sechenov Institute for Regenerative Medicine and Privolzhsky Research Medical University) and Austria (TU Graz), which describes multi-parameter imaging of decellularized pericardial biomeshes in an implanted mouse model. One of highlights of the study is the finding that conjugated polymer-based O2 nanosensors can bind and remain bound to the biomeshes in live animal for extended period of time and thus used for subsequent O2 imaging in live animal and ex vivo. This confirms high usability of conjugated nanoparticle sensors previously developed by our team for such emerging applications as monitoring of tissue regeneration, tumour imaging and others. The work has been published in Frontiers in Bioengineering and Biotechnology journal. Full text can be assessed here . Twitter link .

Dr. Ruslan Dmitriev  recently presented a talk at the Biophysical Society 2020 Annual Meeting, in San Diego Convention Center, California, USA. In his talk, Ruslan summarised recent group developments in a multiparameter imaging of stem cell metabolism in the small intestinal organoid model. He focused on measuring oxygenation of live intestinal organoids, assessing mitochondrial polarisation and combining O2 with NAD(P)H redox microscopy analyses. He also received  Travel Award from the Biophysical Society to attend this meeting. More information on the meeting can be found on Twitter .  The abstract of presentation published in Biophysical Journal supplement can be viewed here .