Publication alert: Phasor-FLIM visualizes and quantifies polluting nanoplastic particles in live intestinal epithelium

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Increased micro- and nanoplastic (MNP) pollution and its poorly understood biomedical impact raises questions on their cell and tissue uptake mechanisms and effects on the absorptive tissues. Dmitriev’s team reports a new microscopy-based approach to perform dynamic imaging of dye-modified micro- and nanoplastics (MNP). When combined with stem cell-derived intestinal organoids, with controlled apical and basal polarity, this approach enables for sensitive detection and quantification of MNPs, their internalization and biological effects. 

The work was published in Light: Science & Applications, big thanks to all collaborators and researchers involved, especially Irina, Hang (first 'big paper' in PhD) and Bert!

We hope to get this research line funded and expand towards studying effects of MNPs on the brain, tooth development and other tissues!

 

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