Intracellular probes for imaging oxygen concentration: how good are they? (review)

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Dr. R. Dmitriev and Prof. D. Papkovsky have jointly co-authored review article in Methods and Applications in Fluorescence journal (IOP publications). The article provides short and concise overview of nearly all existing and optical luminescent probes suitable for quantification of intracellular oxygen in living cells. While the number of "novel O2 sensors" appears in the literature every year (at least 2-5 O2 probes per year), the critical analysis and cross-comparison between existing small molecule and nanoparticle sensor probes are normally missing. The review tries to perform classification among all the reported structures to answer such questions as "toxicity", "cell specificity", "best suitable biological model" etc.

This review complements the previously published review articles on exhaustive classification of biological applications of quenched-phosphorescence O2 sensors and probes (Papkovsky and Dmitriev, Chemical Society Reviews, 2013) and general overview article on area of quantitative O2 sensing in cells and tissues (Dmitriev and Papkovsky, CMLS 2012).

The article is a part of special issue "Focus on luminescent imaging with optical chemical sensors" and is available for FREE:
http://iopscience.iop.org/2050-6120/3/3/034001/article

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