Update on the blog function

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Since June-2019 our blog will mainly focus on the research activity of Dr. Ruslan Dmitriev's group.

If you are interested in research activity of Prof. Dmitri Papkovsky (Laboratory of Biophysics and Bionalalysis, University College Cork), please visit his official webpage:
http://publish.ucc.ie/researchprofiles/D003/dpapkovsky

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New publication: evaluation of GelMA as a Matrigel replacement for small intestinal organoids

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      In our new study (collaboration between Ghent University and Rousselot BV) we report application of GelMA (gelatin methacryloyl) hydrogels with tuneable mechanical properties and added laminin to the culture of the small intestinal organoids. We found that mechanical properties alone are not sufficient for basement membrane support, resulting in polarity reversion, in contrast to the Matrigel-grown cultures. Altogether, observed polarity reversion phenomenon highlights importance of the further research in biochemical factors, directing cell polarity in the epithelial cells, while it also provides a tractable way for producing 'apical-out' organoids. Congratulations to Lenie (for her work on this MSc research project), Irina (for her supervision and driving force), Thomas and Ruben for expertise with gelatins and Bert for expertise with pig intestinal organoids. The work has been published in the Journal of Tissue Engineering (Open Access): https://journals.sagepub...
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Publication alert: Phasor-FLIM visualizes and quantifies polluting nanoplastic particles in live intestinal epithelium

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  Increased micro- and nanoplastic (MNP) pollution and its poorly understood biomedical impact raises questions on their cell and tissue uptake mechanisms and effects on the absorptive tissues. Dmitriev’s team reports a new microscopy-based approach to perform dynamic imaging of dye-modified micro- and nanoplastics (MNP). When combined with stem cell-derived intestinal organoids, with controlled apical and basal polarity, this approach enables for sensitive detection and quantification of MNPs, their internalization and biological effects.  The work was published in Light: Science & Applications , big thanks to all collaborators and researchers involved, especially Irina, Hang (first 'big paper' in PhD) and Bert! We hope to get this research line funded and expand towards studying effects of MNPs on the brain, tooth development and other tissues! Press-release on Eurekalert (14-09-2025)  
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Lab Photo: June 2025

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Up to date photo of our team!   Nore, Irina, Johanna, Magali, Angela, Michele, Gabriele, Teresa*, Sara* and Hang First row: Ruslan  *Sara and Teresa are visiting PhD students funded by MSCA-DN Horizon project FLIMagin3D. 
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