Brief updates for Academic Year of 2023-2024
(video: time lapse FLIM of endocytosis in human colon cancer cells using LysoSensor Green, (C) Dmitriev Lab, 2023)
Some key updates for this period:
- Successful start of FLIMagin3D project, with the 3 new PhD students (Hang, Michele and Gabriele) + visiting (via secondments) PhD students, joining our team to address challenges in multi-parameter FLIM of organoids and multicellular spheroids, advancing imaging & probes for cell oxygenation, FLIM-FRET, tissue mechanics and biofabricated inter-species communities. More about the FLIMagin3D can be found here: https://www.flimagin3d.com/
- Some visiting scientists with exciting projects, including Dr. A. Russegger, R. Harkhoe, partners from OsteoNet Horizon MSCA Staff Exchange network
- Our group (including the microscopes!) has relocated to the new 'The Core' / MREB3 research building at UZ Gent campus of Ghent University. This was a bit stressful period of late autumn - winter months but we happy to say that we survived it and now are back to operation
- We finalised, submitted and published some new exciting research (see below). More to come!
Some recent research articles and preprints:
- Fluorescence Intensity and Fluorescence Lifetime Imaging Microscopies (FLIM) of Cell Differentiation in the Small Intestinal Organoids Using Cholera Toxin (book chapter, protocol)
- GDF15 mediates inflammation-associated bone loss through a brain-bone axis (Preprint, under review)
- Probing organoid metabolism using Fluorescence Lifetime Imaging Microscopy (FLIM): The next frontier of drug discovery and disease understanding (review article)
- Bottom‐Up Extrusion‐Based Biofabrication of the Osteoid Niche
- 2D fibrillar osteoid niche mimicry through inclusion of visco-elastic and topographical cues in gelatin-based networks
- DMT1-dependent endosome-mitochondria interactions regulate mitochondrial iron translocation and metastatic outgrowth
- Tunable Self-Referenced Molecular Thermometers via Manipulation of Dual Emission in Platinum (II) Pyridinedipyrrolide Complexes
- Live Microscopy of Multicellular Spheroids with the Multimodal Near-Infrared Nanoparticles Reveals Differences in Oxygenation Gradients
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