Metabolic Imaging & Tissue engineering Group News

Dr. Ruslan Dmitriev has attended the European Charter Meeting of the Tissue Engineering and Regenerative Medicine International Society ( TERMIS-EU ), held in Uppsala, Sweden during 28 June - 1 July. This time, the meeting gathered 800+ participants from regenerative medicine and adjacent research areas. Dr. Dmitriev co-chaired the session 'Non-destructive imaging for TERM' and presented an invited lecture on multi-parametric imaging of oxygen in scaffold free and scaffold-based 3D tissue models.

The artwork created by PhD candidate J. Jenkins and Dr. R. Dmitriev was chosen as Cover image for June issue of ACS Sensors journal. This issue features the recent article of the group on new NAD(P)H -sensitive fluorescent dye made in collaboration with Roche Diagnostics GmbH and University of Regensburg, Germany.

Prof. D. Papkovsky and Dr. A. Zhdanov have participated in recent study published in Cell Host & Microbe journal. In collaboration with Prof. U. Knaus and Dr. G. Aviello (University College Dublin) they studied the production of reactive oxygen species in NOX-dimerization partner knock-out mice during the infection of colon by various bacteria strains. The full text can be found here .

Dr. R. Dmitriev, PhD candidate J. Jenkins and Prof. D. Papkovsky, in collaboration with Regensburg Institute of Organic Chemsitry and Roche Diagnostics (Germany), have developed a new fluorescent "turn-on" probe for NAD(P)H detection in cancer cells. Such red fluorescent probe works in "end-point" assay formats, however it is highly compatible with both 2D (adherent cell cultures) and 3D (tumour spheroid) cell models. The probe can be used for multi-parametric imaging of cell metabolism in advanced in vitro and  ex vivo models of cancer. The manuscript published in ACS Sensors journal can be found here .

In February 2016, Dr. R. Dmitriev and PhD candidate J. Jenkins attended 60th Biophysical Society Meeting (Feb 27- Mar 2), held in Los Angeles, California. Dr. R. Dmitriev has presented platform talk on multi-parametric O2 imaging in 3D cell models; J. Jenkins has presented a poster on application of O2-sensitive nanoparticles to study the function of Ca/Mn-transporting ATPase SPCA2. More details on the meeting can be found here . Most of the members of the Lab also attended Europtrode 2016 meeting, held in Graz, Austria, on March 20-23: Dr. Dmitriev has delivered a talk on copolymer nanoparticle O2 probes for live cell imaging, Prof. D. Papkovsky presented a poster about applications of O2-sensitive probes for physiology, PhD candidate C. Kelly has presented a poster on new O2-sensitive materials for food-related applications, PhD candidate N. O'Donnell has presented a poster about encapsulation of O2 probe in protein nanoparticles. Europtrode is one of the largest...

Dr. S. Banerjee, PhD candidate C. Kelly and Prof. D. Papkovsky in collaboration with Prof. J. Kerry have published a comprehensive review article describing the applications of optical quenched phosphorescence measurements in food packaging. The review article has been published in Trends in food science & technology journal. The full text of the publication can be found here .

Dr. S. Banerjee, Prof. D. Papkovsky in collaboration with Moscow State University, Russia have published an article in Sensors and Actuators B journal, describing the preparation of O2-sensitive sensor films based on polyolefin fibers.  This material is produced by recently developed solvent-crazing method. The full text of the article can be found here .