Modeling the dynamics of hypoxia inducible factor-1α (HIF-1α) within single cells and 3D cell culture systems

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The long-term collaboration with University of Liverpool, UK has focused on modeling of oxygen diffusion across complex 3D cell models such as tumor spheroids. The mathematical model based on measurements performed by Dr. A. Fercher and Prof. D. Papkovsky on wide-field PLIM microscope, was recently published in Mathematical Biosciences journal.

The full-text can be found here.

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