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Crown ethers help to design advanced nanobiosensors for 3D tissue models
Fluorescence imaging helps studying biological processes in live cells, tissues, animals and humans in a minimally invasive way, to advance the basic, cancer and brain research, from the lab to the bedside. State-of-the-art biosensing nanoparticles are renown for exceptional brightness and stability, unmatched by the fluorescent dyes and fluorescent proteins. However, even such advanced materials as nanoparticles often suffer from poor performance, complex interaction with biomolecules and cells, when challenged with real biological models, such as brain tissue. In search of new ways of improving brain tissue staining with polymer nanoparticles, the collaborative team including researchers from University College Cork, Graz University of Technology (Austria), University of Maryland (USA) and Empa (Switzerland) and led by Dr. Ruslan Dmitriev discovered that widely known RL100 cationic polymer can be successfully combined with the new generation of deep red fluorescent ion-se