A novel effect of DMOG on cell metabolism: direct inhibition of mitochondrial function precedes HIF target gene expression

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Drs. A. Zhdanov, I. Okkelman and Prof. D. Papkovsky in collaboration with Dr. S. Melgar (Alimentary Pharmabiotic Centre, UCC) published a joint research paper reporting the HIF-independent effect of dimethyloxalylglycine (DMOG) on cell metabolism in Biochimica et Biophysica Acta (BBA) - Bioenergetics Journal.
Over the recent years, DMOG was commonly used to inhibit HIF (Hypoxia Inducible Factor) pathways through inhibition of prolyl hydroxylases without paying attention to its direct inhibition of mitochondrial respiration - presumably through inhibition of "glutamine/ 2-oxoglutarate metabolic axis", as the authors suggest.

The full-text of the article can be found here.

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