Imaging oxygen in neural cell and tissue models by means of anionic cell-permeable phosphorescent nanoparticles

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A new paper entitled "Imaging oxygen in neural cell and tissue models by means of anionic cell-permeable phosphorescent nanoparticles" just have been published by the team in CMLS journal. This is result of joint efforts of team members with Department of Anatomy and Neuroscience (UCC), Graz University of Technology (Graz, Austria) and RCSI (Dublin).
The paper describes development and application of novel multi-modal nanoparticle O2 probes intended for high-resolution imaging in diverse range of neural cell models, including 2D cultures of primary cells, multi-cellular aggregates and live brain slices. As a proof-of-concept, the multiplexed detection of O2 in relation to distribution of neural progenitor cells was performed. We hope that this probe, termed PA2 will become a potent tool for broad area of neuroscientists and scientists working in related areas.


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